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专利名称：FC RIIB-SPECIFIC ANTIBODIES AND
METHODS OF USE THEREOF
发明人：JOHNSON, Leslie, S.,HUANG, Ling,GERENA,
Robyn
申请号：EP07812341.1申请日：20070626公开号：EP2029173B1公开日：20160720
摘要：The present invention relates to antibodies or fragments thereof thatspecifically bind Fc³RIIB, particularly human Fc³RIIB, with greater affinity than saidantibodies or fragments thereof bind Fc³RIIA, particularly human Fc³RIIA. The presentinvention also provides the use of an anti-Fc³RIIB antibody or an antigen-binding
fragment thereof, as a single agent therapy for the treatment, prevention, management,or amelioration of a cancer, preferably a B-cell malignancy, particularly, B-cell chroniclymphocytic leukemia or non-Hodgkin's lymphoma, an autoimmune disorder, aninflammatory disorder, an IgE-mediated allergic disorder, or one or more symptomsthereof. The invention provides methods of enhancing the therapeutic effect oftherapeutic antibodies by administering the antibodies of the invention to enhance theeffector function of the therapeutic antibodies. The invention also provides methods ofenhancing efficacy of a vaccine composition by administering the antibodies of theinvention.
申请人：MACROGENICS INC
地址：US
国籍：US
代理机构：Patent Boutique LLP
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